# Compare RealTime-CTMS vs CRIO 2026 | Capterra > Unsure of what to choose? Check Capterra to compare RealTime-CTMS and CRIO based on pricing, features, product details, and verified reviews. Source: https://www.capterra.com/compare/126679-166083/RealTime-CTMS-vs-Clinical-Research-IO --- # RealTime-CTMS vs CRIO Features and Cost Comparison Last updated May 13th, 2026 Provider data verified by our Software Research team, and reviews moderated by our Reviews Verification team.[Learn more](https://www.capterra.com/our-story/) Your comparison: RealTime-CTMSCRIO2/4 selected [RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/)[4.9 (66)](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) [CRIO](https://www.capterra.com/p/166083/Clinical-Research-IO/)[4.5 (21)](https://www.capterra.com/p/166083/Clinical-Research-IO/reviews/) [## RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/)[4.9 (66)](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) Starting Price $500.00/month Value-for-Money 4.8 Functionality 4.7 Ease of Use 4.7 Customer Service 4.9 Reviews Sentiment RA MZ Based on [66 reviews](#user-reviews) Positive 66 Neutral 0 Negative 0 [## CRIO](https://www.capterra.com/p/166083/Clinical-Research-IO/)[4.5 (21)](https://www.capterra.com/p/166083/Clinical-Research-IO/reviews/) Starting Price $200.00/month Value-for-Money 4.4 Functionality 4.4 Ease of Use 4.4 Customer Service 4.7 Reviews Sentiment CB JG JH Based on [21 reviews](#user-reviews) Positive 19 Neutral 0 Negative 2 ## Send this comparison chart to my inbox ### Fill out the form and we'll send a list of the top-rated software based on real user reviews directly to your inbox. ## Summary * * * Features in Clinical Trial Management Software Best performer 42 / 50 Only RealTime-CTMS - Compliance Management - Data Verification - Drag & Drop 39 / 50 Only CRIO - CRF Tracking User satisfaction User satisfaction 4.9 User reviews[66](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) Ease of use 4.7 Functionality 4.7 Value for money 4.8 Customer support 4.9 User satisfaction 4.5 User reviews[21](https://www.capterra.com/p/166083/Clinical-Research-IO/reviews/) Ease of use 4.4 Functionality 4.4 Value for money 4.4 Customer support 4.7 Price starts from Price starts from $500Other, Per Month - Free version - Free trial Price starts from $200Flat Rate, Per Month - Free version - Free trial Best for Best for RealTime eClinical Solutions has platforms that can scale to meet the demands of Sponsors and CROs, Research Sites, Multi-site Networks, Academic Medical Centers and Hospital-based Research Systems. Best for Research sites, sponsors and CROs. For sites, an enterprise tool to streamline operations and improve productivity. For sponsors and CROs, an eSource/EDC platform for remote monitoring. ## User reviews Pros & cons RA Ravi A. Director of Clinical Administration > "It excels in document management (eDocs), data capture (eSource), and patient..." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___5084470) TD Tim D. Manager > "It’s so in-depth that it can seem daunting at times" [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___4769919) MPZ Maria Paula Z. Finance Assistance > "I also love the training program that covers every user's needs, and the customer..." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___6253710) GA Giovanna A. Director of Operations > "ESource does not have logic/edits build in to help the the research staff when..." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___2487075) LM Luis M. Clinical Research Supervisor > "The UI is clean and intuitive." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___4289605) MW Melonie W. Research Data Manager > "It is HARD to navigate this software." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___3285357) LM Luis M. Clinical Research Supervisor > "All you need is in one place and it’s easy to understand thanks to the thorough..." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___4289605) MW Melonie W. Research Data Manager > "It is NOT intuitive (and I'm a digital native)." [See full review](https://www.capterra.com/p/126679/RealTime-CTMS/#Capterra___3285357) [View Reviews](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) Not enough reviews ## User interface 4.88 (66) [CRIO](https://www.capterra.com/p/166083/Clinical-Research-IO/) 4.52 (21) ### Features RealTime-CTMS Top features 42/50 - 21 CFR Part 11 Compliance - Access Controls/Permissions - Activity Dashboard - Activity Tracking - Ad hoc Reporting - AI Copilot - Alerts/Notifications - API - Audit Management - Audit Trail - Calendar Management - Clinical Study Management - Compliance Management - CRF Tracking - Customizable Forms - Customizable Reports - Data Capture and Transfer - Data Import/Export - Data Synchronization - Data Verification - Data Visualization - Digital Signature - Document Imaging - Document Management - Document Storage - Double Data Entry - Drag & Drop - Electronic Data Capture - EMR/EHR - Enrollments/Onboarding - Financial Management - Forms Management - Generative AI - HIPAA Compliant - Inventory Management - Monitoring - Patient Management - Patient Monitoring - Patient Recruiting - Progress Tracking - Randomization - Real-Time Data - Real-Time Monitoring - Real-Time Reporting - Reminders - Reporting & Statistics - Role-Based Permissions - Scheduling - Third-Party Integrations - Trial Design [See all features](https://www.capterra.com/p/126679/RealTime-CTMS/#features) CRIO 39/50 - 21 CFR Part 11 Compliance - Access Controls/Permissions - Activity Dashboard - Activity Tracking - Ad hoc Reporting - AI Copilot - Alerts/Notifications - API - Audit Management - Audit Trail - Calendar Management - Clinical Study Management - Compliance Management - CRF Tracking - Customizable Forms - Customizable Reports - Data Capture and Transfer - Data Import/Export - Data Synchronization - Data Verification - Data Visualization - Digital Signature - Document Imaging - Document Management - Document Storage - Double Data Entry - Drag & Drop - Electronic Data Capture - EMR/EHR - Enrollments/Onboarding - Financial Management - Forms Management - Generative AI - HIPAA Compliant - Inventory Management - Monitoring - Patient Management - Patient Monitoring - Patient Recruiting - Progress Tracking - Randomization - Real-Time Data - Real-Time Monitoring - Real-Time Reporting - Reminders - Reporting & Statistics - Role-Based Permissions - Scheduling - Third-Party Integrations - Trial Design [See all features](https://www.capterra.com/p/166083/Clinical-Research-IO/#features) ### Recognition No recognitions have been awarded to RealTime-CTMS No recognitions have been awarded to CRIO ### Deployment & support RealTime-CTMS Deployment - Cloud, SaaS, Web-Based - Desktop Mac - Desktop Windows - Desktop Linux - On-Premise Windows - On-Premise Linux - Desktop Chromebook - Mobile Android - Mobile iPhone - Mobile iPad Support - Email/Help Desk - FAQs/Forum - Knowledge Base - Phone Support - 24/7 (Live rep) - Chat Training - In Person - Live Online - Webinars - Documentation - Videos CRIO Deployment - Cloud, SaaS, Web-Based - Desktop Mac - Desktop Windows - Desktop Linux - On-Premise Windows - On-Premise Linux - Desktop Chromebook - Mobile Android - Mobile iPhone - Mobile iPad Support - Email/Help Desk - FAQs/Forum - Knowledge Base - Phone Support - 24/7 (Live rep) - Chat Training - In Person - Live Online - Webinars - Documentation - Videos ### Company Details RealTime-CTMS - By RealTime eClinical Solutions - Located in United States - Founded in CRIO - By Clinical Research IO - Located in United States - Founded in 2015