# CRIO Software Pricing, Alternatives & More 2026 | Capterra > With the help of Capterra, learn about CRIO Software - reviews, pricing plans, popular comparisons to other Clinical Trial Management products and more. Source: https://www.capterra.com/p/166083/Clinical-Research-IO --- # CRIO Software Review 2026: Features, Integrations, Pros & Cons Last updated on March 13, 2026 Provider data verified by our Software Research team, and reviews moderated by our Reviews Verification team. Independent research methodology Capterra’s researchers use a mix of verified reviews, independent research and objective methodologies to bring you selection and ranking information you can trust. While we may earn a referral fee when you visit a provider through our links or speak to an advisor, this has no influence on our research or methodology. [Learn more](https://www.capterra.com/resources/proprietary-data-research/) How Capterra verifies reviews Capterra carefully verified over 2.5 million+ reviews to bring you authentic software experiences from real users. Our human moderators verify that reviewers are real people and that reviews are authentic. They use leading tech to analyze text quality and to detect plagiarism and generative AI. [Learn more](https://www.capterra.com/resources/how-we-verify-reviews/) How Capterra ensures transparency Capterra lists all providers across its website—not just those that pay us—so that users can make informed purchase decisions. Capterra is free for users. Software providers pay us for sponsored profiles to receive web traffic and sales opportunities. Sponsored profiles include a link-out icon that takes users to the provider’s website. [Learn more](https://www.capterra.com/resources/how-we-ensure-transparency/) [Description](#description)[Use cases](#use-cases)[Alternatives](#alternatives)[Features](#features)[Pricing](#pricing)[Integrations](#integrations)[Support](#support)[Reviews](#reviews) CRIO ## What is CRIO? An intuitive eSource, lab routing, and CTMS solution for research sites. Using CRIO, sites can save favorite procedures; build customized source templates; capture source data quickly and accurately; mark up labs; and share visits with their monitors for review. Recruiting helps manage patients and campaigns, and enables one-click calling and texting. Finances calculates receivables and invoiceables as the visits are being completed. We are a premium service at an affordable price. ## What is CRIO used for? [Clinical Trial Management](https://www.capterra.com/clinical-trial-management-software/)[Electronic Data Capture](https://www.capterra.com/electronic-data-capture-software/) Top alternative Featured Overall rating Based on 21 user reviews Reviews sentiment Positive 90% Neutral 0% Negative 10% Starting price $200 Flat Rate, Per Month Free trial not available Capterra Shortlist charts the highest-rated and most popular products... Our "Best of" badge program showcases products with the highest ratings... Our "Best of" badge program showcases products with the highest ratings... Do you work for CRIO?[Manage this product listing](https://digitalmarkets.gartner.com/get-listed/claim-bx?url=https://www.clinicalresearch.io/&name=CRIO) ## Compare with a popular alternative Capterra selects software alternatives based on relevant features, verified user reviews and user interactions. Placement may be influenced by client status. ### CRIO 4.5 (21) VS. [4.9 (66)](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) Starting Price $200 Flat Rate, Per Month Starting Price $500 Other, Per Month Free Trial Free Version Pricing Options Free Trial Free Version Ease Of Use 4.4 (21) Ease Of Use 4.7 (66) Value For Money 4.4 (20) Value For Money 4.8 (58) Customer Service 4.7 (20) Customer Service 4.9 (64) ## CRIO alternatives [4.5 (83)](https://www.capterra.com/p/200364/Florence-eBinders/reviews/) Starting price Contact vendor for pricing Pricing Options Free Trial Free Version User Rating 95% of reviewers rated it above 4 stars [4.8 (6)](https://www.capterra.com/p/275503/SiteLink/#reviews) Starting price Contact vendor for pricing Pricing Options Free Trial Free Version User Rating 100% of reviewers rated it above 4 stars [4.9 (21)](https://www.capterra.com/p/133931/ClinCapture/reviews/) Starting price $2000.00 Per User, Per Month Pricing Options Free Trial Free Version User Rating 100% of reviewers rated it above 4 stars [4.7 (204)](https://www.capterra.com/p/143532/Castor-EDC/reviews/) Starting price Contact vendor for pricing Pricing Options Free Trial Free Version User Rating 98% of reviewers rated it above 4 stars [View all alternatives](https://www.capterra.com/p/166083/Clinical-Research-IO/alternatives/) ## Features Features with the highest number of reviews are displayed first. Those that have no reviews appear next, sorted alphabetically. 21 CFR Part 11 Compliance 5.0 (6) 100.00% of 6 reviewers that rated this feature as important or highly important Shows that electronic documents are authentic and linked to specific records Document Management 4.3 (6) 100.00% of 6 reviewers that rated this feature as important or highly important Store, manage, and track all electronic documents in a centralized location Financial Management 4.2 (6) 100.00% of 6 reviewers that rated this feature as important or highly important Plan, manage, and track the financial activities of an individual or organization HIPAA Compliant 5.0 (6) 83.33% of 6 reviewers that rated this feature as important or highly important Compliant with HIPAA, which sets standards for sensitive patient data protection Scheduling 4.3 (6) 100.00% of 6 reviewers that rated this feature as important or highly important Plan availability and assign specific time slots for tasks and resources Patient Management 4.8 (5) 100.00% of 5 reviewers that rated this feature as important or highly important Managing and tracking patient health, progress, communication, and treatment plans CRIO 53 features Shows that electronic documents are authentic and linked to specific records Define levels of authorization for access to specific files or systems Dashboard to view the status of ongoing processes, identify current incidents and track past activities Track and document all activities across devices, networks, and other systems Generate one-off reports that meet information requirements Alerts or notifications of various types such as pop-up messages, sounds, banners, or badges Application programming interface that allows for integration with other systems/databases Manage the process of evaluating documents or requests submitted for approval A record of all activities within the system, including user access, changes made, etc. Track and manage schedules and meetings via an integrated calendar Tools to manage single or multiple clinical studies within a centralized platform Configure existing workflows to meet your organization's needs Collect and track all case report forms (CRFs) within a centralized repository Add customized logos and colors to align with company branding Customize data fields to support various needs and use cases Customize contracts and forms to collect specific information Alter the layout and content of reports Pre-designed layouts that can be customized to match preferences and requirements Import, collect, and capture data from multiple sources Automatically retrieve and pull information from documents, websites, images, data sets, and other sources Import and export data to and from software applications Manage and store data in a database Graphical representation of data Electronic signing method that validates the authenticity and integrity of a digital document Store, manage, and track all electronic documents in a centralized location Store and organize documents in a centralized system Import, collect, and capture data from multiple sources Digitally sign online documents Create and securely store digital patient records Manage the enrollment and onboarding of all new members and accepted applications Plan, manage, and track the financial activities of an individual or organization Store, manage and track all forms in a centralized location Compliant with HIPAA, which sets standards for sensitive patient data protection Observe and track the demand, usage, progress or quality of a system, product, or user Manage and support multiple languages Managing and tracking patient health, progress, communication, and treatment plans Observing and tracking a patient's health status, condition, and wellbeing Helps clinical trials/labs get patients for participation. Reporting on how each user, task or process has advanced since its initiation Receive data and information in real time Active monitoring of systems, applications, or networks Active reporting of data and metrics Timed notification for any upcoming task, deadline, appointment, or activity Capture data electronically Collection, analysis, and representation of numerical data and generation of reports to understand various patterns View and track pertinent metrics to find patterns and gain insights from data Set & manage permission levels based on user roles and restrict access to only authorized individuals Plan availability and assign specific time slots for tasks and resources Securely stores data to prevent data loss or breaches Set up connections to third-party platforms to improve business processes Allows clinics and academic institutions to create trials and studies from scratch. Manage user accounts, profiles, roles, permissions, and other details across applications, devices or networks Create, design and manage workflows for repetitive tasks Features 4.4 (21) 4.4 Based on 21 reviews ## Pricing Value for money 4.4 (20) Licensing $200.00 Flat Rate,Per Month Value for money 4.4 (20) 4.4 Based on 20 reviews ## Integrations [ Microsoft Outlook](https://www.capterra.com/p/227138/Microsoft-Outlook/) ## Support, customer service and training options Customer Service 4.7 (20) Support - Email/Help Desk - FAQs/Forum - Knowledge Base - Phone Support - 24/7 (Live rep) - Chat Training - In Person - Live Online - Webinars - Documentation - Videos Deployment - Web - Android - iPhone/iPad Typical users - Freelancers - Small businesses - Mid size businesses - Enterprises Customer Service 4.7 (20) 4.7 Based on 20 reviews ## User reviews Overall rating 4.5 Based on 21 reviews Filter by rating 5(16) 4(3) 3(0) 2(1) 1(1) Mentioned topic Sorted by most recent CB Christine B. Sub-Investigator Hospital & Health Care ### "CRIO - a great e-source" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 March 7, 2025 Overall, CRIO is easy to use for source documentation. The customer support is top notch. They assign one person to our account and she responds quickly and efficiently to any needs that arise and also makes time to meet with our team as needed. Pros CRIO has an excellent interface for electronic source with plenty of room to add additional paper documents as needed and electronically sign them. Cons The recruitment module (or perhaps our usage of it) is a bit clunky with lots of required steps. Every patient has 2 profiles, which are linked, but it's odd. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. NS Naina S. Regulatory manager Hospital & Health Care ### "Great tool" 4.0 Overall Rating 4.0 4.0 Ease of Use 4.0 4.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 September 6, 2024 Pros Esource and econsent options are really great Cons Connectivity issues can cause disruption during visits Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. DT Derek T. Research Director Hospital & Health Care ### "Bugs Bugs and more Bugs" 2.0 Overall Rating 2.0 2.0 Ease of Use 2.0 2.0 Features 2.0 2.0 Customer Service 1.0 1.0 Likelihood to Recommend 2/10 August 25, 2021 The software has not lived up to the expectation, and their growing price point has made it a thorn in the side of their long-time customers. Pros This software has a clean user interface and the price point was lower than most competitors. Cons CRIO was new to the market when we signed up. They promised routine and frequent updates to improve the software. What we got was prioritizing poorly planned and implemented useless features over fixing the bug and issues in their core product. The e-regulatory is almost completely useless. Switched from [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Price and e-Regulatory Features Alternatives considered [RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/) [Allegro CTMS](https://www.capterra.com/p/126004/Allegro-CTMS/) Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. Response from Vendor August 26, 2021 Hi Derek, Thank you for your response. My name it Tony Sciucco and I'm the Director of Customer Success here at CRIO. We'd love an opportunity to connect with you directly regarding your feedback and have a more in depth conversation. Could you reach out to me directly at tony.sciucco@clinicalresearch.io to set up a time to speak? Thanks and looking forward to connecting. Tony RR Rod R. Research Director Hospital & Health Care ### "Great product for the sites" 5.0 Overall Rating 5.0 5.0 Ease of Use 3.0 3.0 Features 4.0 4.0 Customer Service 3.0 3.0 Likelihood to Recommend 10/10 August 19, 2021 It's been great. Pros It has everything a site should need to run a study. Cons Would like to see eConsent added to the product. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. Response from Vendor August 26, 2021 Hi Rod, Thank you for your review. My name is Tony Sciucco and I'm the Director of Customer Success here at CRIO. I'd love the opportunity to connect with you directly to dive a bit deeper in some of your rankings, pros, cons, etc. Feel free to email me directly so we can set a time to connect! Hope to hear from you soon, Tony JG James G. Medical Director Medical Practice ### "CRIO - finally and all in one clinical research management software." 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 June 22, 2021 Pros For an investigator, the most impactful feature of CRIO is the ability to monitor a subjects process, review and sign off on ancillary studies from anywhere a computer, tablet or cell phone can connect to the CRIO server. The days of piles of paper charts with sticky notes to lead the investigator to new data to review is over. A simple mouse click puts all investigators 'to do' items at his/her fingertips. Cons A module for informed consent electronic signature for subjects and research staff would be desirable. Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. VV Vipul V. Research Director Research ### "One of the most comprehensive systems for clinical research!" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 June 8, 2021 We had been looking for a system that is very easy to use, had multiple features that cater to clinical research (scheduling, payment tracking, eSource, archiving etc) for a very long time but none of the existing systems could provide a complete package.......until I came across CRIO. The team is very knowledgeable and extremely responsive. To take it a step above, they are very receptive of the needs of the clients and regularly change and update their system to better suit our needs with new and refined features. Pros The CTMS aspect of the system is amazing. All the different modules and features are built in nicely with ease of use, simplicity yet extremely efficient. Cons I think an App for this feature would be extremely helpful. Switched from [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. DW Donte W. CEO Pharmaceuticals ### "Clinical Researcher Life with CRIO" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 June 7, 2021 Pros The patient monitoring, financial management and using one systems to streamline our process has main our operation run more efficiently. Cons Making the change from paper source and using the CRIO platform entirely was the hardest adjustment. It was the same with making the change from paper charts to EMR. Alternatives considered [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Reasons for choosing CRIO We decided on CRIO based on the systems ability to integrate with all aspects or our organization. The platform functions in an inclusive capacity that integrated all clinical research areas (i.e. regulatory, clinical coordination, quality assurance, CRO monitoring, contract management). Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. JR Jodi R. Senior Regulatory Specialist Research ### "Seamless record keeping at the tip of your fingers" 5.0 Overall Rating 5.0 5.0 Ease of Use 4.0 4.0 Features 4.0 4.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 June 3, 2021 Pros CRIO is very user friendly, comprehensive, and easy to implement. We were able to train staff and begin utilizing CRIO 100% within 3 weeks of purchase. Cumbersome tasks, such as charting are now streamlined, allowing us to become more productive and better concentrate on our patient population. Cons The eReg function is cumbersome and not quite as user friendly as the rest of the CRIO software. It would be great if it had the same look and feel as the majority of the suite, and if it were not billed separately. Switched from [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Clinical Conductor was not user friendly AT ALL. We were 6 months in and still unable to implement it! Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. KL Kelly L. Regulatory Coordinator Research ### "CRIO review " 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 June 3, 2021 Amazing customer service. the chat now button is a lifesaver ! Pros the ease of uploading documents and keeping track Cons I would like to be able to add multiple documents into one upload without having to print them and scan in as one file Review source Incentivized review: software users are invited to submit an honest review and offered a nominal incentive for their time and effort. All incentivized reviews are subject to our verification process prior to publication. JH Jill H. President Research ### "If you can believe it, It just keeps GETTING BETTER" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 October 27, 2020 We have found their platform to be very user-friendly and it helps with every aspect of managing a clinical study at our site. From patient recruitment to invoicing for a final payment they cover everything for us. Pros I originally signed on to Clinical Research IO three years ago for an eSource solution. Since then I have switched to their CTMS solution, eRegulatory solution as well. We also started using their Recruitment module, texting/calling solution, and patient stipends. EVERY MODULE is fantastic. What I believe is their strongest suit, however, is their customer service and dedication to continued quality and enhancements. They keep adding to their services and really are a "total solution" company for sites. Cons The final piece I'd like to see from them is eConsent.... but I'm told that's coming so I'm very much looking forward to this solution. Alternatives considered [RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/) Reasons for choosing CRIO Clinical Research IO seemed to flow better and was more intuitive to us than RealTime. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. [View all Reviews](https://www.capterra.com/p/166083/Clinical-Research-IO/reviews/) ## Top-rated software of 2026 ### Fill out the form and we'll send a list of the top-rated software based on real user reviews directly to your inbox. Popular comparisons [RealTime-CTMS vs CRIO](https://www.capterra.com/compare/126679-166083/RealTime-CTMS-vs-Clinical-Research-IO)  Independent research methodology Capterra's researchers use a mix of verified reviews, independent research and objective methodologies to bring you selection and ranking information you can trust. While we may earn a referral fee when you visit a provider through our links or speak to an advisor, this has no influence on our research or methodology. [Learn more](https://www.capterra.com/resources/proprietary-data-research/) How Capterra verifies reviews Capterra carefully verified over 2.5 million+ reviews to bring you authentic software experiences from real users. Our human moderators verify that reviewers are real people and that reviews are authentic. They use leading tech to analyze text quality and to detect plagiarism and generative AI. [Learn more](https://www.capterra.com/resources/how-we-verify-reviews/) How Capterra ensures transparency Capterra lists all providers across its website—not just those that pay us—so that users can make informed purchase decisions. Capterra is free for users. Software providers pay us for sponsored profiles to receive web traffic and sales opportunities. Sponsored profiles include a link-out icon that takes users to the provider's website. [Learn more](https://www.capterra.com/resources/how-we-ensure-transparency/)