# CRIO Reviews 2026. Verified Reviews, Pros & Cons | Capterra > Is CRIO the right Clinical Trial Management solution for you? Explore 21 verified user reviews from people in industries like yours to make a confident choice. Source: https://www.capterra.com/p/166083/Clinical-Research-IO/reviews --- CRIO 4.5 (21) [View alternatives](https://www.capterra.com/p/166083/Clinical-Research-IO/alternatives/) Provider data verified by our Software Research team, and reviews moderated by our Reviews Verification team. [Learn more](https://www.capterra.com/our-story/) * * * Last updated March 13th, 2026 # Reviews of CRIO Ease of use 4.4 Customer Service 4.7 ## Pros and Cons in Reviews CB Christine B Sub-InvestigatorHospital & Health Care, 201 - 500 employeesUsed the software for: 1-2 years. “CRIO has an excellent interface for electronic source with plenty of room to add additional paper documents as needed and electronically sign them.“ March 7, 2025 JG James G Medical DirectorMedical Practice, 11 - 50 employeesUsed the software for: More than 2 years. “For an investigator, the most impactful feature of CRIO is the ability to monitor a subjects process, review and sign off on ancillary studies from anywhere a computer, tablet or cell phone can connect to the CRIO server. “ June 22, 2021 JH Jill H PresidentResearch, 2 - 10 employeesUsed the software for: More than 2 years. “What I believe is their strongest suit, however, is their customer service and dedication to continued quality and enhancements. “ October 27, 2020 ## Showing most helpful reviews Showing 1-21 of 21 Reviews Sort by: Most Helpful Rating Company Size Reviewer's Role Length of Use Frequency of Use LA W. Founder Used the software for: 6-12 months ### "Super efficient, friendly support, proactive company focused on site needs & industry demands. " November 2, 2017 5.0 The time spent in clinic and entering data has been cut to less than half. We are continuing to learn about all of the functions of this software and have not been dissappointed in anything yet. The capabilities are endless and the cost is affordable. Big pharma should jump at the chance at having real time data available. This has been a game changer at our site. We only have 2 coordinators so we were limited in our study load. We have doubled our study load within 6 months of starting with CRIO. You will not find a single system that offers all that CRIO does and for the price too! Pros This is the creme de la creme of clinical research software. There are so many modules and training that it will take some time to get used to but you will never be sorry. If you seriously commit to learning and using this system you will save so much time from capturing data real time to decreasing errors and deviations. I absolutely love the reponse time from the CRIO team and the "live chat" feature has saved our site from having any major meltdowns due to the learning curve. Our site is almost completely paperless thanks to this amazing software. Comments from CRA's : "this is the wave of the future" "your site is so far ahead in the game, why aren't all sites using this?" " what is it called again?" The game changer for our site was the financial tracker module. We are a small site so using Fresh Books, an EMR, a CTMS, and entering data in respective EDC's took an incredible amount of time... time wasted entering data trifold and trying to track what we are owed vs paid & costs to our vendors , study staff etc. Major bonus points for this system that our site was not looking for was the recruiting module. This system is truly a one stop shop. Better is efficiency in what we do, how we do it, without compromising the integrity of the data. Data entry errors across multiple systems compromises data, creates queries and wastes time. CRIO does interface with other data systems making data entry at the site occur one time. Imagine that! Review Source JR Jodi R. Senior Regulatory Specialist Research Used the software for: 1-2 years ### "Seamless record keeping at the tip of your fingers" June 3, 2021 5.0 Pros CRIO is very user friendly, comprehensive, and easy to implement. We were able to train staff and begin utilizing CRIO 100% within 3 weeks of purchase. Cumbersome tasks, such as charting are now streamlined, allowing us to become more productive and better concentrate on our patient population. Cons The eReg function is cumbersome and not quite as user friendly as the rest of the CRIO software. It would be great if it had the same look and feel as the majority of the suite, and if it were not billed separately. Switched from [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Clinical Conductor was not user friendly AT ALL. We were 6 months in and still unable to implement it! Review Source DT Derek T. Research Director Hospital & Health Care Used the software for: 2+ years ### "Bugs Bugs and more Bugs" August 25, 2021 2.0 The software has not lived up to the expectation, and their growing price point has made it a thorn in the side of their long-time customers. Pros This software has a clean user interface and the price point was lower than most competitors. Cons CRIO was new to the market when we signed up. They promised routine and frequent updates to improve the software. What we got was prioritizing poorly planned and implemented useless features over fixing the bug and issues in their core product. The e-regulatory is almost completely useless. Alternatives considered [RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/)[Allegro CTMS](https://www.capterra.com/p/126004/Allegro-CTMS/) Switched from [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Price and e-Regulatory Features Review Source Response from Clinical Research IO August 26, 2021 Hi Derek, Thank you for your response. My name it Tony Sciucco and I'm the Director of Customer Success here at CRIO. We'd love an opportunity to connect with you directly regarding your feedback and have a more in depth conversation. Could you reach out to me directly at tony.sciucco@clinicalresearch.io to set up a time to speak? Thanks and looking forward to connecting. Tony JH Jill H. President Research Used the software for: 2+ years ### "If you can believe it, It just keeps GETTING BETTER" October 27, 2020 5.0 We have found their platform to be very user-friendly and it helps with every aspect of managing a clinical study at our site. From patient recruitment to invoicing for a final payment they cover everything for us. Pros I originally signed on to Clinical Research IO three years ago for an eSource solution. Since then I have switched to their CTMS solution, eRegulatory solution as well. We also started using their Recruitment module, texting/calling solution, and patient stipends. EVERY MODULE is fantastic. What I believe is their strongest suit, however, is their customer service and dedication to continued quality and enhancements. They keep adding to their services and really are a "total solution" company for sites. Cons The final piece I'd like to see from them is eConsent.... but I'm told that's coming so I'm very much looking forward to this solution. Alternatives considered [RealTime-CTMS](https://www.capterra.com/p/126679/RealTime-CTMS/) Reason for choosing CRIO Clinical Research IO seemed to flow better and was more intuitive to us than RealTime. Review Source DW Donte W. CEO Pharmaceuticals Used the software for: 2+ years ### "Clinical Researcher Life with CRIO" June 7, 2021 5.0 Pros The patient monitoring, financial management and using one systems to streamline our process has main our operation run more efficiently. Cons Making the change from paper source and using the CRIO platform entirely was the hardest adjustment. It was the same with making the change from paper charts to EMR. Alternatives considered [Clinical Conductor CTMS](https://www.capterra.com/p/88069/Clinical-Conductor-CTMS/) Reason for choosing CRIO We decided on CRIO based on the systems ability to integrate with all aspects or our organization. The platform functions in an inclusive capacity that integrated all clinical research areas (i.e. regulatory, clinical coordination, quality assurance, CRO monitoring, contract management). Review Source CB Christine B. Sub-Investigator Hospital & Health Care Used the software for: 1-2 years ### "CRIO - a great e-source" March 7, 2025 5.0 Overall, CRIO is easy to use for source documentation. The customer support is top notch. They assign one person to our account and she responds quickly and efficiently to any needs that arise and also makes time to meet with our team as needed. Pros CRIO has an excellent interface for electronic source with plenty of room to add additional paper documents as needed and electronically sign them. Cons The recruitment module (or perhaps our usage of it) is a bit clunky with lots of required steps. Every patient has 2 profiles, which are linked, but it's odd. Review Source NS Naina S. Regulatory manager Hospital & Health Care Used the software for: 1-2 years ### "Great tool" September 6, 2024 4.0 Pros Esource and econsent options are really great Cons Connectivity issues can cause disruption during visits Review Source JG James G. Medical Director Medical Practice Used the software for: 2+ years ### "CRIO - finally and all in one clinical research management software." June 22, 2021 5.0 Pros For an investigator, the most impactful feature of CRIO is the ability to monitor a subjects process, review and sign off on ancillary studies from anywhere a computer, tablet or cell phone can connect to the CRIO server. The days of piles of paper charts with sticky notes to lead the investigator to new data to review is over. A simple mouse click puts all investigators 'to do' items at his/her fingertips. Cons A module for informed consent electronic signature for subjects and research staff would be desirable. Review Source VR Verified Reviewer Business Development Pharmaceuticals Used the software for: 6-12 months ### "A Fundamentally Broken product that will frustrate you to no end! DO NOT BUY THIS" September 24, 2020 1.0 Absolutely the worst product I have ever used. Even typing in a diagnosis becomes an issue. Everything is so much more complicated than it needs to be. This is a waste of money and this company should not even be in business. Pros Nothing - this product is not worth anything because it will never truly work. You will never stop experiencing problems. Cons This product is absolutely FULL of broken functionalities and errors. There isn't a day go by where a basic function stops working and I need to contact their customer support. They never fix these issues permanently and leave most of the implementation work for you to do. They nickel and dime and ultimately their software designers choose the most idiotic choices that leave the software unnecessarily complicated to use. DO NOT BUY THIS SOFTWARE. If you do, you will experience what I have and you will remember this review! Review Source Ryan L. Clinical Research Manager Used the software for: 6-12 months ### "Excellent clinical research software with great value for the cost." November 13, 2017 4.0 Pros \-UI is very clean and easily navigated. -Source creation that is simple for anyone with some advanced features. -Frequent updates and improvements. -Payment model that makes sense for research sites. -External logins allow monitors to leave comments directly on the eSource form! Cons \-Simplistic source creation doesn't lend itself to specific needs. As an ophthalmology practice, best-corrected visual acuity is impossible to adequately and efficiently capture on this platform. That said, I haven't seen a system that can do much better. -They took an interesting approach of starting with a complicated form and simplifying it as you answer questions rather than vice versa. I don't dislike it but would prefer the alternative for the purposes of clinical research. Review Source VV Vipul V. Research Director Research Used the software for: 2+ years ### "One of the most comprehensive systems for clinical research!" June 8, 2021 5.0 We had been looking for a system that is very easy to use, had multiple features that cater to clinical research (scheduling, payment tracking, eSource, archiving etc) for a very long time but none of the existing systems could provide a complete package.......until I came across CRIO. The team is very knowledgeable and extremely responsive. To take it a step above, they are very receptive of the needs of the clients and regularly change and update their system to better suit our needs with new and refined features. Pros The CTMS aspect of the system is amazing. All the different modules and features are built in nicely with ease of use, simplicity yet extremely efficient. Cons I think an App for this feature would be extremely helpful. Review Source David S. President & CEO Used the software for: 1-2 years ### "One of the best User experiences in Research and Software I have experienced." January 11, 2018 5.0 Pros It is both online (website) and available in an App. Since October 2016, we have experienced zero downtime. Even better: the have an integrated Chat feature...which they answer, respond to, and fix any/all issues, and answer all questions. Cons When we started with CRIO, they did not have an integrated database we could use for recruiting. They do now. When we started, they did not have a financial component we could use to track work done. They do now. The only outstanding issues are: no regulatory component and no ability to consent patients with CRIO. Review Source Takoda R. Clinical Project Manager Used the software for: 1-2 years ### "I have worked with CRIO eSource first as a CRA and then as a site owner for Clinical Trials. " April 30, 2018 5.0 Improved data quality while decreasing the time required to manage a study. Pros In my experience the strongest feature of CRIO's eSource is the ability to review data remotely. As both a CRA and a site owner, remote data review is imperative to ensure patient safety, data quality, and to identify any potential errors as quickly as possible. CRIO streamlines Clinical Research data collection to cut down on Study Coordinator and CRA time all while decreasing unnecessary user errors. There customer support has been very strong and I look forward to seeing there software adopted on a larger scale in Clinical Trials. Cons CROs have not made it a requirement for studies yet. Once CROs are mandating CRIO's software across all research sites for a given study, the CRO's will be able to effectively standardize data collection and truly achieve their goal of being able to perform risk-based monitoring. Review Source NJ Nusrat J. Lead research Coordinator Research Used the software for: 6-12 months ### "Clinical Research IO" September 27, 2019 4.0 I would highly recommend this software for people who working in research industry and managing patients. Pros Clinical Research IO is a user friendly software for patient management. It allows me to serve as a better Lead coordinator of a busy research team by providing all the tools at one place. it reduces the amount of paper documents which take lot of place and easy to send documents for sponsor. it has easy navigation and documents process is very simple. Cons I did not find any problem with this software. It is easy to use and support is available. Only one issue it does not have regulatory no component. Review Source Response from Clinical Research IO October 1, 2019 Hi Nusrat, We do have an e-regulatory module! I would be happy to demo this for you if you'd like to take a look. Feel free to reach out to us! And thank you so much for the review. We are so happy that you are a part of Team CRIO! RR Rod R. Research Director Hospital & Health Care Used the software for: 6-12 months ### "Great product for the sites" August 19, 2021 5.0 It's been great. Pros It has everything a site should need to run a study. Cons Would like to see eConsent added to the product. Review Source Response from Clinical Research IO August 26, 2021 Hi Rod, Thank you for your review. My name is Tony Sciucco and I'm the Director of Customer Success here at CRIO. I'd love the opportunity to connect with you directly to dive a bit deeper in some of your rankings, pros, cons, etc. Feel free to email me directly so we can set a time to connect! Hope to hear from you soon, Tony CM Chelsey M. Quality Control Director/Research Team Manager Research Used the software for: 1-2 years ### "Life Changing! " April 12, 2018 5.0 This software significantly helps with patient management. All in one system that is easy to use. Pros User-friendly! I love that this program makes following protocol requirements for study visits a breeze! It is extremely easy to make adjustments (for example if there are protocol amendments) and the software takes away the stress of forgetting things like re-consenting patients or follow-up evaluations of AEs. Groundbreaking for the research industry! Cons In regards to the cons, I have little/nothing to note. Customer service has been very responsive and easy to talk to; they have resolved most of my issues immediately. Review Source KL Kelly L. Regulatory Coordinator Research Used the software for: 2+ years ### "CRIO review " June 3, 2021 5.0 Amazing customer service. the chat now button is a lifesaver ! Pros the ease of uploading documents and keeping track Cons I would like to be able to add multiple documents into one upload without having to print them and scan in as one file Review Source Colin S. Director of Recruitment Pharmaceuticals Used the software for: Less than 6 months ### "Overall CRIO is the best CTMS product we've reviewed or used." December 15, 2017 5.0 Pros CRIO has \*easily\* the best recruitment functionality of any product available. The integration of CTMS, e-source, and recruiting is largely seamless. The product is very dynamic, and they're constantly improving and upgrading features. Product team are very receptive to user feedback, and the customer service is fantastic. Cons There are annoying bugs that sometimes take a while to be fixed and occasional issues where design doesn't meet the needs of our clinical research site. Review Source JC James C. CEO/Owner Research Used the software for: 6-12 months ### "Absolutely the best Research Site management software on the market." April 27, 2018 5.0 It allows me to serve as a better Principal Investigator, CEO, and owner of a busy research team by providing all the tools I need right at my fingertips. Pros Built by clinical researchers for clinical researchers says it all. This program addresses every concern and limitation of old paper documentation while understanding the detailed requirements of CRAs, Sponsors, and FDA. Fantastic consumer service even after purchase. Cons I have honestly not found a problem with either the software application or the service provided by their administration team. Review Source SA Saul A. Director of Operations Biotechnology Used the software for: Less than 6 months ### "Best and More Complete CTMS in the market. " April 10, 2018 5.0 More management real time of the study data. Save the planet reduce the amount of paper use, reduce the time that subject spend in the clinical site. Increase PI oversight. Just love it Pros Essay set up, easy to work, direct step guidance for us. Tremendous customer response and help desk. Human contact solution, subject payment, and financial integration. Cons None have all you need, I'm not able to find any cons yet. Working on it but every time I found a roadblock the IO team provided me with the tools to overcome or fix the issue. Review Source TH Tricia H. Owner Medical Practice Used the software for: Less than 6 months ### "I absolutely love CRIO. I can not picture running a multi-specialty research site without it. With " January 23, 2018 5.0 Eliminates deviations. Helps sponsor review data in a timely fashion. Use of less paper. Pros Easy to use. Works with the industry. Able to change and update as needed. Able to keep all logs study related electronically. Friendly and punctual help desk. Economically affordable. Training is simple and able to start using right away. Review Source Similar Products Featured ## Related categories [Clinical Trial Management](https://www.capterra.com/clinical-trial-management-software/)[Electronic Data Capture](https://www.capterra.com/electronic-data-capture-software/)