--- title: "Florence eTMF Software Pricing, Alternatives & More 2026 | Capterra" description: "With the help of Capterra, learn about Florence eTMF Software - reviews, pricing plans, popular comparisons to other Clinical Trial Management products and more." source_url: "https://www.capterra.com/p/276610/Florence-eTMF/" page_type: "product" language: "en" publication_date: "2026-10-21" --- # Florence eTMF Software Review 2026: Features, Integrations, Pros & Cons Last updated on October 21, 2026 Provider data verified by our Software Research team, and reviews moderated by our Reviews Verification team. [Description](#description)[Use cases](#use-cases)[Alternatives](#alternatives)[FAQs](#faqs)[Features](#features)[Pricing](#pricing)[Support](#support)[Reviews](#reviews) Florence eTMF ## What is Florence eTMF? Florence Electronic trial master file (eTMF) is the only eTMF that combines ease of use with integrated remote access to study sites on the Florence platform. Implementing an eTMF is critical for Sponsors and CROs that want to increase study capacity, and enable more trials. With over 10,000 research sites connected to the Florence Network, we have an intimate understanding of the research site and the site’s eISF where over 80% of a TMF’s documents originate. ## What is Florence eTMF used for? [Clinical Trial Management](https://www.capterra.com/clinical-trial-management-software/) Overall rating Based on 18 user reviews Reviews sentiment Positive \- Neutral \- Negative \- Starting price Free trial not available Capterra Shortlist charts the highest-rated and most popular products... Our "Best of" badge program showcases products with the highest ratings... Our "Best of" badge program showcases products with the highest ratings... ## Florence eTMF alternatives Highest Rated [4.8 (71)](https://www.capterra.com/p/126679/RealTime-CTMS/reviews/) Starting price $500.00 Per User, Per Month Pricing Options Free Trial Free Version User Rating 100% of reviewers rated it above 4 stars [4.5 (3,579)](https://www.capterra.com/p/79104/Smartsheet/reviews/) Starting price $9.00 Per User, Per Month Pricing Options Free Trial Free Version User Rating 92% of reviewers rated it above 4 stars [4.7 (204)](https://www.capterra.com/p/143532/Castor-EDC/reviews/) Starting price Contact vendor for pricing Pricing Options Free Trial Free Version User Rating 98% of reviewers rated it above 4 stars [4.5 (128)](https://www.capterra.com/p/176283/Visual-Planning/reviews/) Starting price $55.00 Per User, Per Month Pricing Options Free Trial Free Version User Rating 93% of reviewers rated it above 4 stars [View all alternatives](https://www.capterra.com/p/276610/Florence-eTMF/alternatives/) ## FAQs about Florence eTMF Overview ### Which roles and teams benefit most from Florence eTMF? Florence eTMF is most used by clinical trial project managers, clinical research associates, and trial operations leaders who manage essential documents, site activity, and study timelines. Regulatory and IRB liaisons maintain submission records and inspection-ready files, while clinical scientists, research coordinators, and monitors track study documentation, compliance, and follow-up tasks. Answer based on 18 reviews Overview ### What company size and industries is Florence eTMF built for? Florence eTMF is built primarily for enterprise organizations, which represent 50% of reviewers, and the research industry, also at 50%. It serves sponsors, CROs, sites, medical device companies, biotech firms, hospitals, and academic medical centers, with small businesses accounting for 33%. Its primary use case is clinical trial management. Answer based on 18 reviews Features and Usability ### What are the key features of Florence eTMF? Florence eTMF offers clinical study management, document management and storage, and workflow management for trial records. It also includes 21 CFR Part 11 compliance, HIPAA compliance, digital signatures, audit trail and audit management, role-based permissions and access controls, plus reporting and statistics, alerts and reminders, and third-party integrations. Getting Started and Support ### What training and onboarding options does Florence eTMF offer? Florence eTMF provides webinars, documentation, and videos to help teams get started. Webinars support live, guided training sessions, videos offer visual walkthroughs for specific tasks, and documentation gives written reference material for reviewing steps and product details. Getting Started and Support ### What customer support options does Florence eTMF offer? Florence eTMF provides email/help desk support, an FAQ/forum, and a knowledge base. These channels give users written guidance for common questions and issue tracking, but no reviewer feedback is available to describe response times, helpfulness, or common support frustrations. ## Features AI summary Based on 355 Clinical Trial Management reviews Not all Clinical Trial Management software covers every must-have feature. Here is what Capterra reviewers flag as essential when choosing a solution: - **21 CFR Part 11 Compliance** (**72%** of reviewers rated this feature as critical) - **HIPAA Compliant** (**76%**) - **Electronic Data Capture** (**51%**) Florence eTMF supports **21 CFR Part 11 Compliance** and **HIPAA Compliant**, covering two of the top capabilities buyers look for in Clinical Trial Management software. However, it does not include **Electronic Data Capture**. Instead, the product offers other highly valued features, including **Audit Trail** (**52%**), **Clinical Study Management** (**48%**), and **Document Management** (**54%**). These capabilities help organizations maintain oversight of trial activity, manage study workflows, and keep essential records organized, providing teams with stronger compliance controls and more efficient trial operations. 21 CFR Part 11 Compliance 4.7 (15) 100.00% of 15 reviewers that rated this feature as important or highly important Shows that electronic documents are authentic and linked to specific records HIPAA Compliant 4.8 (12) 116.67% of 12 reviewers that rated this feature as important or highly important Compliant with HIPAA, which sets standards for sensitive patient data protection Audit Trail 4.8 (13) 107.69% of 13 reviewers that rated this feature as important or highly important A record of all activities within the system, including user access, changes made, etc. Clinical Study Management 4.5 (13) 100.00% of 13 reviewers that rated this feature as important or highly important Tools to manage single or multiple clinical studies within a centralized platform Document Management 4.4 (13) 115.38% of 13 reviewers that rated this feature as important or highly important Store, manage, and track all electronic documents in a centralized location Workflow Management 4.4 (12) 116.67% of 12 reviewers that rated this feature as important or highly important Create, design and manage workflows for repetitive tasks Florence eTMF 25 features ### All Features - 21 CFR Part 11 Compliance: Shows that electronic documents are authentic and linked to specific records - Access Controls/Permissions: Define levels of authorization for access to specific files or systems - Activity Dashboard: Dashboard to view the status of ongoing processes, identify current incidents and track past activities - Activity Tracking: Track and document all activities across devices, networks, and other systems - Alerts/Notifications: Alerts or notifications of various types such as pop-up messages, sounds, banners, or badges - Audit Management: Plan, schedule, and execute organization's accounts and assets to ensure compliance with policies and laws - Audit Trail: A record of all activities within the system, including user access, changes made, etc. - Clinical Study Management: Tools to manage single or multiple clinical studies within a centralized platform - Customizable Forms: Customize contracts and forms to collect specific information - Data Capture and Transfer: Import, collect, and capture data from multiple sources - Data Import/Export: Import and export data to and from software applications - Digital Signature: Electronic signing method that validates the authenticity and integrity of a digital document - Document Management: Store, manage, and track all electronic documents in a centralized location - Document Storage: Store and organize documents in a centralized system - Drag & Drop: Assemble applications and processes by dragging over and arranging pre-built components - HIPAA Compliant: Compliant with HIPAA, which sets standards for sensitive patient data protection - Monitoring: Observe and track the demand, usage, progress or quality of a system, product, or user - Progress Tracking: Reporting on how each user, task or process has advanced since its initiation - Real-Time Monitoring: Active monitoring of systems, applications, or networks - Reminders: Timed notification for any upcoming task, deadline, appointment, or activity - Reporting & Statistics: Collection, analysis, and representation of numerical data and generation of reports to understand various patterns - Role-Based Permissions: Set & manage permission levels based on user roles and restrict access to only authorized individuals - Third-Party Integrations: Set up connections to third-party platforms to improve business processes - User Management: Manage user accounts, profiles, roles, permissions, and other details across applications, devices or networks - Workflow Management: Create, design and manage workflows for repetitive tasks --- Features 4.2 (18) 4.2 Based on 18 reviews ## Pricing Value for money 4.5 (10) Value for money 4.5 (10) 4.5 Based on 10 reviews ## Support, customer service and training options Customer Service 4.8 (12) Support - Email/Help Desk - FAQs/Forum - Knowledge Base - Phone Support - 24/7 (Live rep) - Chat Training - In Person - Live Online - Webinars - Documentation - Videos Deployment - Web - Android - iPhone/iPad Typical users - Freelancers - Small businesses - Mid size businesses - Enterprises Customer Service 4.8 (12) 4.8 Based on 12 reviews ## User reviews Overall rating 4.6 Based on 18 reviews Filter by rating Counts reflect reviews available in this feed. 5(10) 4(8) 3(0) 2(0) 1(0) Mentioned topic Recent reviews first, then most helpful Sedalia C. Continuous Improvement Quality & Safety Manager Used the software for: 1-3 years ### "Fantastic eTMF!" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 February 13, 2023 Pros Florence has incredibly user-friendly software. Cons I would like slightly more control on timeline in the implementation phase. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Sr. Manager Clinical Trials Used the software for: 1-3 years ### "Early user's appreciative review" 5.0 Overall Rating 5.0 5.0 Ease of Use 4.0 4.0 Features 4.0 4.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 February 15, 2023 Florence has enables us to go from paper TMF, to electronic TMF- which has been fantastic. We have learned a lot about electronic systems. Pros It has been easy to use Florence, especially once the binders are set up and the roles are established. It has been great for getting signatures from sites, and easily maintaining our TMF and site eISFs. It is so nice to have all the documents in a softare that is easy to navigate, and is constantly improving/ adding new features to make it user friendly. Cons The set up does take time, but there is a learning curve for everything. Especially systems as customizeable as Florence. The delegation of authority log feature has not worked as smoothly as I anticipated, given how many changes to study staff and site PIs that there are. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Clinical Trial Project Manager Used the software for: 1-3 years ### "Great Potential" 4.0 February 17, 2023 Pros The email documents to the binder feature is a huge positive. Granting user access it also simple, and the ability to create digital template logs is beneficial. Also, the ability to change the title of a document if there is an error is a huge plus. I've worked in other eTMFs and to change a document name you have to make it "obsolete" and go through tons of other processes to correct it. Cons There is no search function. You cannot search for a specific document if you do not know which folder it is stored in. The binder structure for my studies is complicated, so I sometimes spend 10 minutes trying to decipher where a colleague or site might have saved a specific document. Also, when moving a document, you need to select all the folders to put it in which can be a bit time consuming. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Director Clinical Affairs Used the software for: 1-3 years ### "Ease of Use and Compliance " 4.0 Overall Rating 4.0 4.0 Ease of Use 4.0 4.0 Features 3.0 3.0 Customer Service 5.0 5.0 Likelihood to Recommend 8/10 February 16, 2023 Overall, Florence onboarding and customer service is amazing. They go above and beyond and are always supportive. Although pricing is more than average and there is some downsides overall the experience is great. Pros Florence has the ability to implement a regulatory compliant trial management file system easily for both you and all your clinical sites. Implementing changes within your file structure is easy. Uploading documents and adding users are easy to complete with simple toggles of buttons and drag and drops. Cons Florence still has some challenges in terms of bulk file uploading for example when a new site is onboarded and was previously on paper or transferred. Also, there is no interface to upload images or Dicoms. This is part of our TMF but we have no ability to add these to Florence. Also a CTMS would be great. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. VR Verified Reviewer Lead CRA Used the software for: 1-3 years ### "Florence review" 5.0 Overall Rating 5.0 5.0 Ease of Use 4.0 4.0 Features 4.0 4.0 Customer Service 5.0 5.0 Likelihood to Recommend 9/10 February 22, 2023 paper TMF is a difficult endeavor - this cuts study start in half, and allows for consistent and ongoing visibility into the files so you can keep on top of things. Pros The fact that documents are electronic, easily located and retrievableeasy to share with study sites, easy to collect documents and to QC Cons the reporting features are only worthwhile if everyone including your ISF sites use tags and labels staff training and implementation at the sponsor has been uneven so it is of little value.the search function could use some real updating. lets make it folder specific! Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Clinical Trial Project Manager Used the software for: 1-3 years ### "Review" 4.0 Overall Rating 4.0 4.0 Ease of Use 4.0 4.0 Features 4.0 4.0 Customer Service 5.0 5.0 Likelihood to Recommend 7/10 February 13, 2023 Pros Easy to use, signing and redacting features are wonderful and easy to use. Rarely any questions from sites. Cons We use Florence to create a Delegation of Authorities (DOA) Log and it is so difficult to use. You cannot see all site stafrf's responsibilities (Column with A-Z) activities that gives you ellipses after certain amount of letters and our monitors and team constantly need to download the DOA Log to view staff responsibilities then sort through all site staff versions to come to the most recent one. Would be great for you to make a visually easy to see DOA. Would save our team so much time. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer CTS Used the software for: 1-3 years ### "Review of the eTMF Florence" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 8/10 February 16, 2023 Very pleased with the system and the support. Pros It is easy to move around in this program. Cons I would like for it to stay up longer and not time out. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Director, Clinical Research Projects Used the software for: 3-5 years ### "Very good eTMF and document management software" 5.0 Overall Rating 5.0 5.0 Ease of Use 5.0 5.0 Features 5.0 5.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 February 16, 2023 The Florence team helped with software implementation and deployment, and ensured that the team had adequate training. Pros I love the versatility, and easy of use. Cons I don't really have anything I don't like about the software. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Lead CRA Used the software for: 1-3 years ### "Good Software with Room to Improve" 4.0 February 13, 2023 Pros Central document management makes it easy for stakeholders to access and file regulatory documents. Cons The logs are pretty limiting at present and seem to be geared toward tracking information that will not change throughout the trial. It is not conducive for use as a Delegation of Authority log, for example. The Florence team is reportedly working on implementing some of the feedback provided and we look forward to those future changes. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. RE Reviewer Sr Staff Clinical Scientist Used the software for: Less than 1 year ### "Perspective from a Super User" 5.0 Overall Rating 5.0 5.0 Ease of Use 4.0 4.0 Features 4.0 4.0 Customer Service 5.0 5.0 Likelihood to Recommend 10/10 February 13, 2023 I am essentially still learning how to work Florence but learning every time I use it. The training modules are phenomenal. I am just starting with working with a clinical site which where we have run into some roadblocks with permissions and accessibility. Pros The features I most appreciate in this SW is that fact that we have a centralized location for study files which is critical for our company. The training modules are stellar! Cons What I am having challenges currently is compliance and the allowed roles and responsibilities provided to a clinical site to 'manage' their own ISF. We are having to conduct our own Validation as this has been identified as a gap by our Compliance team. Review source Non-incentivized review: any software user can leave a review for any product listed on our site. All submitted reviews are subject to our verification process prior to publication. [View all Reviews](https://www.capterra.com/p/276610/Florence-eTMF/reviews/) ## Top-rated software of 2026 ### Fill out the form and we'll send a list of the top-rated software based on real user reviews directly to your inbox.